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I 1963 startede de to amerikanske psykiatere Marie Nyswander og Vincent Dole [five] en række forsøg med at give metadon til heroinafhængige i USA. Efter at have gennemført disse forsøg konkluderede de to psykiatere, at de heroinafhængige ved indtagelse af metadon kunne fungere normalt; de begyndte at arbejde, genoptog kontakten til gamle venn
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